Response to 'TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro' - authors' reply
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Response to 'TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro' - authors' reply
Arthritis Research and Th erapy could draw such great interest from the readers. Th e following is our response to Ma and colleagues' concerns [1]. In response to the fi rst question, at the beginning of the research we had screened the entire apoptotic pathways using the Rat Apoptosis RT2 Profi ler™ PCR Array (SABiosciences, Frederick, MD, USA), and the result (Table 1 in the original paper [2...
متن کاملResponse to 'TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro'
and colleagues, in which they addressed, on the basis of their previous work, the underlying mechanisms for the protective eff ect of a small component of traditional Chinese herbs, sodium ferulate (SF), on osteoarthritis (OA) [1]. Utilizing the classical in vitro OA chondrocyte model induced by IL-1β, they provided lines of evidence that SF does make a big diff erence to the OA model in a dose...
متن کاملCorrection: TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β- induced rat osteoarthritis chondrocytes in vitro
After publication of our recent article [1], it was brought to our attention that an inaccurate observation was made in the Results section. We stated that diff erent concentrations of SF have no eff ect on normal chondrocytes viability. However, Figure 1 demonstrates that SF concentra tions 500 and 1000 μmol/L signifi cantly increase chondrocytes viability compared with the control group. Th e...
متن کاملTNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro
INTRODUCTION Sodium ferulate (SF) is a natural component of traditional Chinese herbs. Our previous study shows that SF has a protective effect on osteoarthritis (OA). The objective of this study was to investigate the effect of SF on the TNF/TNF receptor (TNFR) signal transduction pathway of rat OA chondrocytes. METHODS Primary rat articular chondrocytes were co-treated with IL-1β and SF. Ch...
متن کاملL-Carnitine potentiates the anti-inflammatory and antinociceptive effects of diclofenac sodium in an experimentally induced knee osteoarthritis rat model
Objective(s): The aim of the present research is to investigate the efficacy of L-carnitine (LC) as a complementary therapy to diclofenac sodium (Dic) treatment in a mono-iodoacetate (MIA) induced knee osteoarthritis (OA) rat model, with respect to pain relief and the underlying pathology.Materials and Methods: Fifty adult male albino ra...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2013
ISSN: 1478-6354
DOI: 10.1186/ar4227